iCloud can replace syncing with iTunes and you won’t need to regularly remember to connect your iPad to your computer. However, I still like to have a local backup on my computer. If I need to restore an iPad, the process will be much quicker than using iCloud over a Wi-Fi connection, especially with a large collection of content. I also find it easier to manage and arrange a large number of apps and folders within iTunes than trying to do all that on the iPad screen. The good news is you can do both – use iCloud and keep a local backup in iTunes on your computer. Here’s more from MacWorld and Apple on the topic.